Andrographis Paniculata Extract: Medicinal Uses and Side Effects
Andrographis paniculata, also known as “Indian knee herb or green antibiotic”, is a herb widely distributed in tropical countries and mostly in the wasteland and isolated patches. The plant is also called as Kalmegh, commonly known as creat or green chiretta, the leaf is a traditional remedy for snake bite, diabetes, dysentery, and malaria. Andrographis paniculata extract contains andrographolide, a bioactive compound with anti-inflammatory, antimicrobial, and antioxidant properties. In this post, we will introduce the medicinal uses of Andrographis paniculata extract.
What is Andrographis paniculata extract?
Andrographis leaves contain diterpene lactones, glycosides and flavonoids, alkaloids, phenols, catechine, saponins, and tannins. In addition, it contains andrographolide, neoandrographolide, tetradecanoic acid, phytol, dioctyl ester, squalene, retinoic acid methyl ester, and ß-sitosterol. Andrographis paniculata extract is the active component extracted from the leaves and stems of this plant, mainly containing andrographolide and other compounds. These components endow Andrographis paniculata extract with powerful anti-inflammatory, antibacterial and immune-regulating effects, making it highly valued in both traditional medicine and modern pharmacology.
The Medical Uses of Andrographis Paniculata Extract
Andrographis paniculata extract is known to possess a variety of pharmacological activities. the major constituent of the extract is implicated towards its pharmacological activity.
- Anti-inflammatory Effects
Andrographolide in Andrographis paniculata extract has a significant anti-inflammatory effect. It can inhibit the release of inflammatory mediators and reduce inflammatory responses. Studies have shown that Andrographis paniculata extract has a certain alleviating effect on inflammatory diseases such as rheumatoid arthritis and enteritis.
- Antibacterial and Antiviral
Andrographis paniculata extract possesses broad-spectrum antibacterial and antiviral activities. It can inhibit the growth of various bacteria and viruses, including influenza virus, herpes virus, and certain drug-resistant strains. This makes Andrographis paniculata extract potentially valuable in the treatment of infectious diseases.
- Immune Regulation
Andrographis paniculata extract can enhance the immune function of the body and increase the activity of immune cells. It is widely used in the prevention and treatment of colds, flu and other respiratory infections, helping the body recover more quickly.
- Antioxidant
Andrographis paniculata extract is rich in antioxidant components, which can neutralize free radicals and reduce the damage of oxidative stress to cells. Long-term consumption of Andrographis paniculata extract can help delay aging and prevent chronic diseases.
- Liver Protection
Studies have shown that Andrographis paniculata extract has a protective effect on the liver. It can alleviate liver damage, promote liver cell regeneration, and has a certain auxiliary therapeutic effect on hepatitis and liver fibrosis.
- Anti-cancer
Andrographolide treatment inhibited the proliferation of different tumor cell lines, representing various types of cancers. The immunostimulatory activity of andrographolide is evidenced by increased proliferation. It also enhanced the α production and CD marker expression, resulting in increased cytotoxic activity of lymphocytes against cancer cells, which may contribute to its indirect anticancer activity.
Andrographis paniculata extract safety and side effects
Andrographis paniculata extract is generally safe at recommended doses. It is widely used in traditional medicine and modern health supplements, and the safety of long-term use has been supported by multiple studies. However, for certain special populations (such as pregnant women, breastfeeding women, and children), it is advisable to consult a doctor before use.
Although Andrographis paniculata extract is considered safe, side effects may still occur in some cases:
- Gastrointestinal discomfort: Some people may experience gastrointestinal discomfort symptoms such as nausea, vomiting and diarrhea after taking Andrographis paniculata extract.
- Allergic reaction: A very small number of people may be allergic to Andrographis paniculata extract, presenting allergic reactions such as rash and itching.
- Low blood pressure: Andrographis paniculata extract may have a blood pressure-lowering effect. Patients with low blood pressure should use it with caution.
- Excessive immune activation: Long-term and high-dose use of Andrographis paniculata extract may lead to excessive activation of the immune system, causing autoimmune diseases.
Usage Recommendations
To ensure the safe use of Andrographis paniculata extract, it is recommended to follow the suggestions below:
- Follow the recommended dosage: Use as directed on the product label or as advised by your doctor, and avoid taking more than the prescribed amount.
- Note drug interactions: Andrographis paniculata extract may interact with other medications (such as anticoagulants, antihypertensives).
- Caution for special groups: pregnant women, lactating women, children and patients with chronic diseases should consult a doctor before use.
- Short-term use: Andrographis paniculata extract is suitable for short-term use. Long-term and high-dose use may increase the risk of side effects.
Conclusion
As a natural herb ingredient, Andrographis paniculata extract possesses a variety of pharmacological effects, including anti-inflammatory, antibacterial, antiviral, immunomodulatory, antioxidant, and liver-protective properties. It has been widely used in both traditional medicine and modern pharmacology. Although Andrographis paniculata extract is generally safe at recommended doses, potential side effects and drug interactions should still be noted during its use. Through rational application, Andrographis paniculata extract can help you maintain health and prevent and treat various diseases.
