Evodia Fruit Extract

Product Details

Evodia is also called Evodia, tea spicy, lacquer, stinky tree, Zuolichunyouzi, Milazi, etc. It is usually divided into large flower Evodia, medium flower Evodia and small flower Evodia. species. Small trees or shrubs, 3-5 meters high, twigs dark purple-red, with buds covered with grayish-yellow or red rust-colored hairs, or sparsely short hairs. The flowering period is from April to June, and the fruiting period is from August to November.

Evodia contains evodiene, ocimene, evodiolide, evodiolide, evodiline, evodiamine, evodiamine, hydroxyevodiamine, evodicarpine, dihydroevodicarpine, cyclic guanosine phosphate, Limonin, evodipicrin, evodipicrin ethyl ester, phellodendron, anthocyanin, isoprene flavonoids, ketones such as evodiidone, evodial essence, steroids, fatty acids, etc., have the functions of dispelling cold and relieving pain, soothing liver and regulating qi. , The effect of helping yang and stopping diarrhea, can be used for abdominal cold pain, cold condensate qi stagnation, liver depression and chest tightness, five-gener diarrhea, spleen and kidney yang deficiency embolism.

• Evodia fruit extract 10:1 20:1 50:1
• Evodiamine 20%-98%

Health Benefits

(1) Anti-tumor effect

Inhibit tumor cell proliferation, induce tumor cell apoptosis and necrosis Evodia can induce apoptosis of human liver cancer, melanoma, cervical cancer and other tumor cells.

(2) Effects on the cardiovascular system

It prevents allergic heart damage. Guinea pigs sensitized with the specific antigen, bovine serum albumin, had reduced coronary flow, significantly lower left ventricular pressure, and increased and prolonged heart rate. Using it can significantly increase the content of CGRP in coronary effluent, improve cardiac function, and shorten the P-R period. It can also inhibit sinus tachycardia and protect the heart from allergic reactions.

(3) Weight loss

Evodiamine can reverse vascular hypertrophy complicated by obesity; it can reduce the content of CGRP in serum and abdominal aorta, and its mechanism of action may be related to regulating the expression of CGRP and TRPV1 in serum, vascular tissue and DRG. It can inhibit the differentiation of human white preadipocytes (HWP) and down-regulate the expression of conserved sequences and proteins in gene promoters, suggesting that evodiamine may have a better effect on preventing obesity.

(4) Anti-inflammatory and analgesic effects

To investigate whether evodiamine can inhibit hypoxia-induced inflammatory response, it was found that evodiamine can dose-dependently inhibit cyclooxygenase and reduce prostaglandin (E2) release. Block hypoxia-induced phosphorylation of AKt, 70kDa ribosomal protein S6 kinase (p70S6K) and 4E-binding protein (4E-BP), modulate hypoxia-inducible factors, significantly inhibit the number of writhings caused by acetic acid, and administer a small amount of evodiamine. The isolated mouse ileum lost its response to sensory nerve stimulation, but retained its response to vagus nerve stimulation. Evodiline exerts analgesic effect through sensory nerve desensitization.

(5) Endocrine system

Evodiamine can directly act on the rat adrenal cortex by reducing the activity of intracellular cyclic adenosine monophosphate-related pathways, inhibiting the activity of steroid hormone production-related enzymes such as 3β-hydroxysteroid dehydrogenase, and reducing and affecting signal transduction. Cells inhibit corticosterone secretion. It can effectively reduce the basic level of testosterone and the secretion of testosterone stimulated by human chorionic gonadotropin, and inhibit the release of testosterone caused by forskolin. Evodiamine also inhibits 8-Br-cAMP and androstenedione-induced testosterone release.

(6) Effects on Alzheimer’s disease

The Morris water maze test was used to detect the effect of evodiamine on the learning and memory ability of Alzheimer’s disease mice. Inflammation-related factors in Alzheimer’s disease. It can improve the cognitive ability of Alzheimer’s disease transgenic mice.