Indole-3-carbinol

Product Details

Indole-3-carbinol is a kind of tumor chemopreventive substance, which can be extracted from cruciferous vegetables (such as broccoli, radish and cauliflower). Indole-3-methanol can inhibit the occurrence and development of many kinds of tumors. At present, there are many anticancer drugs, but no ideal, high-efficiency and low toxicity anticancer drugs have been found. Therefore, the research on high-efficiency, low toxicity and even natural anti-tumor drugs to enrich the prevention and treatment of laryngeal cancer has become the focus and focus of many experts and scholars.

Indole-3-carbinol is derived from the degradation of glucosinolates from Brassica glucosinolates and widely exists in cruciferous vegetables. It inhibits NF- κ B and I κ B α Kinase activation. Indole-3-carbinol was synthesized by Vilsmeier Haack reaction with indole, phosphorus oxychloride and N, N-dimethylformamide as raw materials.

Cruciferous vegetables are rich in dietary fiber, vitamin A, vitamin K, vitamin C, potassium and phytochemicals, especially sulfur-containing compounds, such as glucosinolates. Brassica glucosinolates is a kind of glucosinolates in cruciferous vegetables. It turns into indole-3-methanol with multiple benefits through a series of metabolic processes. Because it contains indole gluconate, cruciferous vegetables and their extracts also have anti estrogen effects, especially indole-3-methanol can increase the excretion of estrogen in urine to balance the hormone level in the body.

Health Benefits

Controlling inflammation:

Chronic inflammation is considered to be the root cause of many health problems, such as heart disease, diabetes, obesity and cancer. Studies have found that higher intake of cruciferous vegetables is associated with decreased inflammatory markers, including tumor necrosis factor α、 Interleukin-1 β And interleukin-6.

Its efficacy may be attributed to the fact that cruciferous vegetables are rich in antioxidants, including β Carotene, vitamin C, kaempferol, indole-3-methanol, etc. can prevent oxidative stress, resist free radical damage and prevent diseases.

Tumor prevention:

Some studies have shown that regular intake of cruciferous vegetables can reduce the incidence rate of gastric cancer, colorectal cancer and lung cancer. The reduced risk of cancer may be related to some anticancer substances contained in cruciferous vegetables, such as selenium and glucosinolate hydrolysates.

• Reduce blood glucose:

Some studies have found that higher intake of cruciferous vegetables is associated with a lower risk of type 2 diabetes. Compared with 0.2 servings of cruciferous vegetables per day, 1.35 servings per day reduced the risk of diabetes by 14%. In addition, cruciferous vegetables are not only rich in dietary fiber, which can slow down the absorption of blood glucose, but also contain many antioxidants and other unique compounds, which can promote blood glucose control.

• Preventing obesity:

Cruciferous vegetables also play an important role in healthy weight loss. A large-scale meta-analysis found that a daily serving of cruciferous vegetables was associated with significant weight loss. Excluding the control of exercise and other dietary factors, a daily serving of cruciferous vegetables alone could reduce an average weight of 0.6 kg in four years.

• Maintain heart health:

Eating cruciferous vegetables can also reduce the incidence rate and mortality of cardiovascular diseases. In one study, it was found that the group with the highest intake of cruciferous vegetables had a 15.8% lower risk of cardiovascular disease than the group with the lowest intake. In addition, some cruciferous vegetables can also improve blood lipids to enhance heart health and reduce the risk of heart disease.