Kaempferol Powder

Product Details

Kaempferol powder is derived from the seeds of locust bean in the fruit of locust horn. The flower of locust flower is called locust flower, the bud is called locust rice, and the fruit is called locust horn. Sophora japonica is contiguous, 1 to 6 cm long and 0.6 to 1 cm in diameter. The surface is yellow-green or yellow-brown, shrunken and rough, and the side of the dorsal suture is yellow. Soft texture, dry and shrinking, easy to break at the shrinkage, yellow-green cross section, sticky. The pulp is slightly gassy, bitter in taste, and the seeds are chewed with a beany smell. More than November-December, the fruit is harvested when the fruit is ripe, and it is cultivated on the side of houses and roadsides.

Sophora japonica contains 9 flavonoids and isoflavones, including genistein, sophora glycosides, sophora biglycosides, kaempferol glycoside-C, sophora flavonoids and rutin, as well as sophorose. The galactomannan is extracted from the seeds. Rich in nutritional value, it is a plant-based traditional Chinese medicine with a long history. What we offering：

• Sophora Japonica Extract 10:1 20:1 50:1
• Troxerutin 95%- 98%
• Quercetin Dihydrate 98%
• Anhydrous quercetin 98%
• Lutin 95%
• L-Rhamnose 98%
• Sophora japonica flavonoids 10- 98%

Health Benefits

• Induction of apoptosis

Apoptosis is the main mechanism of action of various antitumor drugs to inhibit tumor cell proliferation. Caspase (caspase) is involved in the initiation and execution of apoptosis, and an increase in its level can promote apoptosis.

• Regulate the cell cycle

Tumor is a disease in which the regulation mechanism of cell cycle is destroyed, so blocking the cell cycle can inhibit the unlimited proliferation of tumor. Mitogens are key molecules in the transition from G2 to M phase, and activated MPFs play a key role in the G-M phase transition of cells. Cyclin-dependent kinase is the kinase subunit of MPF, and its concentration in cells generally remains constant, but when kaempferol acts on human hepatoma cells, the level of CDK1 decreases and the proportion of cells in G2-M phase increases by 5, indicating that it Can regulate the cell cycle.

• Inhibits angiogenesis

Angiogenesis is the basis of tumor growth, invasion and metastasis, a necessary condition for the formation of solid tumors, and its role in hematological tumors, especially multiple myeloma, has also been confirmed. Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis. Studies have shown that it can inhibit the secretion of VEGF in vitro and in vivo, thereby inhibiting angiogenesis to achieve anti-tumor effects.

• Inhibit tumor metastasis

High levels of matrix metalloproteinase-3 (MMP-3) are associated with strong tumor invasiveness and poor prognosis. MMP-3 can disrupt key extracellular matrix proteins such as fibronectin and collagen. Although most flavonoids have no effect on the secretion of MMP-3, it can significantly inhibit its activity, and can also inhibit highly aggressive human breast cancer cells in a dose-dependent manner, which can be used to prevent tumor invasion and metastasis.

• Antioxidative and prooxidative effects

The unstable free radical groups generated by oxidative stress, such as reactive oxygen species, lipid peroxides, nitric oxide, etc., can damage DNA and induce malignant transformation of cells. By reducing the level of free radicals in cells, the malignancy of tumor cells can be reversed.

• Anti-inflammatory

Inflammatory diseases can induce a variety of cancers, increasing the risk of bladder cancer, cervical cancer, stomach cancer, and more. Inflammatory suppressor mediators or transcription factors in inflammatory cells reduce cancer initiation and spread.